GUCY2F

The protein kinase domain is predicted to be catalytically inactive.

Responsible for the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors (PubMed:7777544). Plays an essential role in phototransduction, by mediating cGMP replenishment (By similarity). May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane (By similarity).

There are 9 conserved cysteine residues in sensory guanylate cyclases, 6 in the extracellular domain, which may be involved in intra- or interchain disulfide bonds.

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Retina. Localized exclusively in the outer nuclear layer and inner segments of the rod and cone photoreceptor cells.

• Photoreceptor outer segment membrane
• Single-pass type I membrane protein

GUC2F, RETGC2, GUCY2F, Retinal guanylyl cyclase 2, RETGC-2, Guanylate cyclase F, Rod outer segment membrane guanylate cyclase 2, GC-F, ROS-GC2

• entrezGene:2986
• omim:300041
• swissprot:P51841

Proteins

124850Da