Gypa
Function
Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane. Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane.
Post-translational modifications
The N-terminal extracellular domain is heavily glycosylated on serine and threonine residues.
Sequence Similarities
Belongs to the glycophorin-A family.
Cellular localization
- Membrane
- Single-pass type III membrane protein
Alternative names
CD235a, Glycophorin-A, Gypa