GYPC
Function
This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells.
Post-translational modifications
O-glycosylated with core 1 or possibly core 8 glycans.
Sequence Similarities
Belongs to the glycophorin-C family.
Tissue Specificity
Glycophorin-C is expressed in erythrocytes. Glycophorin-D and IsoGPC are ubiquitously expressed.
Cellular localization
- Cell membrane
- Single-pass type III membrane protein
- Linked to the membrane via band 4.1.
Alternative names
CD236, GLPC, GPC, GYPC, Glycophorin-C, Glycoconnectin, Glycophorin-D, Glycoprotein beta, PAS-2', Sialoglycoprotein D, GPD