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GZMB

Function

Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse (PubMed:35705808). It cleaves after Asp (PubMed:35705808). Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-E (GSDME), releasing the pore-forming moiety of GSDME, thereby triggering pyroptosis and target cell death (By similarity). Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution (By similarity). Cleaves caspase-3 and -9 (CASP3 and CASP9, respectively) to give rise to active enzymes mediating apoptosis (PubMed:35705808). Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair (PubMed:35705808).

Sequence similarities

Belongs to the peptidase S1 family. Granzyme subfamily.

Cellular localization

  • Secreted
  • Cytolytic granule
  • Delivered into the target cell by perforin.

Alternative names

  • Ctla-1
  • Ctla1
  • Ctla-1
  • Gzmb
  • Ctla1
  • CTLA-1
  • Cytotoxic cell protease 1
  • Fragmentin-2
  • CCP1

Target type

Proteins

Primary research area

Immuno-oncology

Other research areas

  • Immunology & Infectious Disease

Molecular weight

27470Da

We found 8 products in 2 categories

Primary Antibodies

Target

Reactive species

Assay Kits

Target

Reactive species