GZMH
Function
Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication.
Sequence Similarities
Belongs to the peptidase S1 family. Granzyme subfamily.
Tissue Specificity
Constitutively expressed in NK cells.
Cellular localization
- Cytolytic granule
Alternative names
CGL2, CTSGL2, GZMH, Granzyme H, CCP-X, Cathepsin G-like 2, Cytotoxic T-lymphocyte proteinase, Cytotoxic serine protease C, CSP-C