H1-0

Function

Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The histones H1.0 are found in cells that are in terminal stages of differentiation or that have low rates of cell division.

Post-translational modifications

Phosphorylated on Ser-17 in RNA edited version.

ADP-ribosylated on Ser-104 in response to DNA damage.

Sequence Similarities

Belongs to the histone H1/H5 family.

Cellular localization

• Nucleus
• Chromosome
• The RNA edited version has been localized to nuclear speckles. During mitosis, it appears in the vicinity of condensed chromosomes.

Alternative names

H1F0, H1FV, H1-0, Histone H1.0, Histone H1', Histone H1(0)

Database links

swissprot:P07305 swissprot:Q2M2I2 entrezGene:3005 swissprot:Q6FG88 swissprot:Q86WT7 swissprot:Q7Z694 entrezGene:341567 entrezGene:132243 entrezGene:8971 entrezGene:3024 entrezGene:3010 entrezGene:3009 entrezGene:3008 entrezGene:3007 swissprot:Q6ISI1 swissprot:Q92522 swissprot:Q8IZA3 swissprot:Q8N6R3 omim:142210 swissprot:P16401 omim:142220 omim:142708 omim:142709 omim:142710 omim:142711 omim:602785 swissprot:P10412 swissprot:P22492 swissprot:Q3MJ42 swissprot:P16402 swissprot:P16403 swissprot:Q147U8 swissprot:Q02539 entrezGene:3006 swissprot:Q4VB25 swissprot:Q3MJ34