H1-4 phospho T18
Domain
The C-terminal domain is required for high-affinity binding to chromatin.
Function
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).
Involvement in disease
Rahman syndrome
RMNS
An autosomal dominant syndrome characterized by intellectual disability and overgrowth manifesting as increased birth length, height, weight, and/or head circumference.
None
The disease is caused by variants affecting the gene represented in this entry.
Post-translational modifications
H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter.
Acetylated at Lys-26. Deacetylated at Lys-26 by SIRT1.
Citrullination at Arg-54 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.
ADP-ribosylated on Ser-150 in response to DNA damage.
Sequence Similarities
Belongs to the histone H1/H5 family.
Cellular localization
- Nucleus
- Chromosome
- Mainly localizes in heterochromatin. Dysplays a punctuate staining pattern in the nucleus.
Alternative names
H1F4, HIST1H1E, H1-4, Histone H1.4, Histone H1b, Histone H1s-4, H1T18p