H1-8

Function

May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling (By similarity).

Sequence Similarities

Belongs to the histone H1/H5 family.

Tissue Specificity

Oocyte-specific.

Cellular localization

• Cytoplasm
• Nucleus
• Chromosome

Alternative names

H1FOO, H1OO, OSH1, H1-8, Histone H1.8, Histone H1oo, Oocyte-specific histone H1, Oocyte-specific linker histone H1, osH1

Database links

swissprot:Q8IZA3 swissprot:Q86WT7 swissprot:Q6FG88 swissprot:Q2M2I2 swissprot:Q3MJ42 swissprot:Q3MJ34 swissprot:Q4VB25 swissprot:Q02539 swissprot:Q147U8 omim:602785 swissprot:P16403 entrezGene:3010 omim:142210 omim:142220 omim:142708 omim:142709 entrezGene:341567 entrezGene:132243 entrezGene:8971 entrezGene:3024 swissprot:Q7Z694 entrezGene:3009 entrezGene:3008 entrezGene:3007 entrezGene:3006 entrezGene:3005 swissprot:Q8N6R3 swissprot:Q92522 swissprot:Q6ISI1 swissprot:P16401 swissprot:P22492 swissprot:P10412 swissprot:P07305 omim:142711 omim:142710 swissprot:P16402