H2-D1
Function
Involved in the presentation of foreign antigens to the immune system.
Post-translational modifications
Polyubiquitinated in case of infection by murid herpesvirus 4, by the viral E3 ligase K3 (mK3), leading to target the protein for rapid degradation by the endoplasmic reticulum-associated degradation (ERAD) system. Ubiquitination takes place on lysine, as well as serine and threonine residues present in the cytoplasmic tail. Hydroxylated serine and threonine residues in the cytoplasmic tail are subject to ubiquitination via ester bonds instead of the classical isopeptide linkage (Probable).
Hydroxylation of residues in the cytoplasmic tail.
Sequence Similarities
Belongs to the MHC class I family.
Cellular localization
- Membrane
- Single-pass type I membrane protein
Alternative names
H-2D(K), H2-D1