H2AB2
Domain
The docking domain is responsible for the weaker heterodimerization with H2B.
Function
Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo. They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase. They associate with spliceosome components and are required for mRNA splicing. May participate in spermatogenesis.
Sequence Similarities
Belongs to the histone H2A family.
Tissue Specificity
Present in mature sperm.
Cellular localization
- Nucleus
- Chromosome
- Associated with the active X chromosome and with autosomes, while it is absent from the inactive X chromosome and excluded from Barr bodies.
Alternative names
H2AFB2, H2AB3, H2ABBD, H2AFB, H2AFB3, H2AB2, Histone H2A-Bbd type 2/3, H2A Barr body-deficient, H2A.Bbd