HAGH
Function
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
Pathway
Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.
Sequence Similarities
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
Tissue Specificity
Expressed in liver and kidney.
Cellular localization
- Isoform 1
- Mitochondrion matrix
- Isoform 2
- Cytoplasm
Alternative names
GLO2, HAGH1, HAGH, Glyoxalase II, Glx II