HAMP
GeneName
HAMP
Summary
HAMP, also known as hepcidin or Hepcidin-25, is a 9 kDa peptide hormone primarily expressed in the liver and secreted into the bloodstream. It plays a vital role in iron homeostasis by regulating iron absorption in the intestine and iron release from macrophages and hepatocytes. Hepcidin acts as a negative regulator of iron transport across the plasma membrane, influencing the activity of iron transporters such as ferroportin. Additionally, it is involved in the immune response, contributing to the body's defense against bacterial and fungal infections by modulating iron availability to pathogens.
Importance
HAMP is relevant to: - Iron metabolism disorders, such as anaemia of chronic disease and hereditary haemochromatosis, due to its regulatory role in iron homeostasis - Infectious diseases, as it helps limit iron availability to pathogens, thereby influencing the outcome of infections - Inflammatory conditions, where hepcidin levels can be altered, impacting iron metabolism and immune function - Research into potential therapeutic targets for diseases associated with iron dysregulation and inflammation.
Top Products
For researchers investigating HAMP, we recommend two excellent primary antibodies. The first is the well-cited polyclonal antibody, Anti-Hepcidin-25 antibody (ab30760), which has garnered 51 citations, reflecting its reliability in the field. This antibody is particularly effective for Western blotting (WB) and immunohistochemistry (IHC), making it a versatile choice for various applications. Additionally, we offer the recombinant antibody, Anti-Hepcidin-25 antibody [EPR18074] (ab187778). This monoclonal antibody is validated for use in Western blotting (WB) and provides the added benefit of batch-to-batch consistency that comes with recombinant products. Together, these antibodies provide robust options for studying HAMP in your research.
Abcam Product Citation Summary
The data indicates that the HAMP antibody (ab30760) has been utilised in various studies focusing on hepcidin expression and regulation, particularly in mouse heart and liver tissues. Additionally, it has been applied in human brain tissue research related to Alzheimer's disease and in rat oral mucosa studies concerning oral ulcerative mucositis. This suggests a significant role of HAMP in different biological contexts.
Abcam Product Citation Table
Function
Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin/SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma (PubMed:22682227, PubMed:29237594, PubMed:32814342). Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes (PubMed:22306005).
Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa (PubMed:11034317, PubMed:11113131).
Involvement in disease
Hemochromatosis 2B
HFE2B
A juvenile form of hemochromatosis, a disorder of iron metabolism with excess deposition of iron in a variety of organs leading to their failure, bronze skin pigmentation, hepatic cirrhosis, arthropathy and diabetes. The most common symptoms of juvenile hemochromatosis at presentation are hypogonadism and cardiomyopathy.
None
The disease is caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the hepcidin family.
Tissue Specificity
Highest expression in liver and to a lesser extent in heart and brain. Low levels in lung, tonsils, salivary gland, trachea, prostate gland, adrenal gland and thyroid gland. Secreted into the urine and blood (PubMed:11034317). Expressed by hepatocytes (PubMed:15124018).
Cellular localization
- Secreted
Alternative names
HEPC, LEAP1, UNQ487/PRO1003, HAMP, Hepcidin, Liver-expressed antimicrobial peptide 1, Putative liver tumor regressor, LEAP-1, PLTR