HAO2

Oxidase that catalyzes the oxidation of medium and long chain hydroxyacids such as 2-hydroxyhexadecanoate and 2-hydroxyoctanoate, to the correspondong 2-oxoacids (PubMed:10777549). Its role in the oxidation of 2-hydroxy fatty acids may contribute to the general pathway of fatty acid alpha-oxidation (Probable). Active in vitro with the artificial electron acceptor 2,6-dichlorophenolindophenol (DCIP), but O2 is believed to be the physiological electron acceptor, leading to the production of H2O2. Is not active on glycolate, glyoxylate, L-lactate and 2-hydroxybutanoate (PubMed:10777549).

Lipid metabolism; fatty acid metabolism.

Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

Expressed in the liver and kidney.

• Peroxisome

HAOX2, GIG16, HAO2, 2-Hydroxyacid oxidase 2, Cell growth-inhibiting gene 16 protein, Long chain alpha-hydroxy acid oxidase, Long-chain L-2-hydroxy acid oxidase

• entrezGene:51179
• omim:605176
• swissprot:Q9NYQ3

Proteins

Neuroscience

38839Da