HASPIN

Function

Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle.

Post-translational modifications

Autophosphorylated on both serine and threonine residues (By similarity). Strongly phosphorylated during mitosis but this does not appear to significantly affect its intrinsic kinase activity. Phosphorylation by AURKB is required for full activity toward histone H3 at 'Ser-3' in mitosis.

Sequence Similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Haspin subfamily.

Tissue Specificity

Strongly expressed in testis. Also present in thymus and bone marrow and low levels observed in prostate, intestine, lung, spleen and lymph node. Expressed in fetal skin, liver, kidney and small intestine and also in proliferating but not non-proliferating cell lines.

Cellular localization

• Nucleus
• Chromosome
• Cytoplasm
• Cytoskeleton
• Spindle
• Nuclear during interphase and associates with the chromosomes and spindle apparatus during mitosis.

Alternative names

GSG2, HASPIN, Serine/threonine-protein kinase haspin, Germ cell-specific gene 2 protein, H-haspin, Haploid germ cell-specific nuclear protein kinase

Database links

swissprot:Q8TF76 swissprot:P27037 entrezGene:83903 entrezGene:92 omim:102581 omim:609240