Havcr1
Domain
Possesses an immunoglobulin V-like domxain, a mucin domain, a single transmembrane region, and a cytoplasmic tail containing a tyrosine phosphorylation motif.
Function
Phosphatidylserine receptor that plays an important functional role in regulatory B-cells homeostasis including generation, expansion and suppressor functions (PubMed:21821911, PubMed:25645598, PubMed:32668241). As P-selectin/SELPLG ligand, plays a specialized role in activated but not naive T-cell trafficking during inflammatory responses (PubMed:24703780). Controls thereby T-cell accumulation in the inflamed central nervous system (CNS) and the induction of autoimmune disease (PubMed:24703780). Regulates also expression of various anti-inflammatory cytokines and co-inhibitory ligands including IL10 (PubMed:25582854, PubMed:25645598). Acts as a regulator of T-cell proliferation (PubMed:15793576). May play a role in kidney injury and repair (By similarity).
Sequence Similarities
Belongs to the immunoglobulin superfamily. TIM family.
Tissue Specificity
Expressed by stimulated T-cells. Expressed during primary antigen stimulation (PubMed:11725301). Expressed at higher levels on B rather than T-cells, both constitutively and after activation (PubMed:21821911).
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
Alternative names
CD365, Kim1, Tim1, Timd1, Havcr1, Hepatitis A virus cellular receptor 1 homolog, HAVcr-1, Kidney injury molecule 1, T cell immunoglobulin and mucin domain-containing protein 1, T cell membrane protein 1, T-cell immunoglobulin mucin receptor 1, KIM-1, TIMD-1, TIM-1