HBG1

Developmental stage

Expressed until four or five weeks after birth. Detected at very low levels in adults, where it constitutes about 1% of the total hemoglobin. In contrast, the levels of fetal hemoglobin F (two alpha chains and two gamma chains) are increased in children and adults with beta-thalassemia or sickle-cell disease. In cases of homozygous alpha-thalassemia, homotetrameric hemoglobin Bart's is highly expressed and is the predominant form of hemoglobin after 10 weeks of gestation. Its levels increase steadily after 10 weeks of gestation and until birth (at protein level).

Function

Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.

Post-translational modifications

Acetylation of Gly-2 converts Hb F to the minor Hb F1.

Sequence Similarities

Belongs to the globin family.

Tissue Specificity

Red blood cells.

Alternative names

PRO2979, HBG1, Hemoglobin subunit gamma-1, Gamma-1-globin, Hb F Agamma, Hemoglobin gamma-1 chain, Hemoglobin gamma-A chain

Database links

swissprot:P69891 entrezGene:3048 entrezGene:3047 swissprot:P69892 omim:142250 omim:142200