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Hemoglobin subunit gamma-2

Developmental stage

Expressed until four or five weeks after birth.

Function

Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.

Involvement in disease

Cyanosis transient neonatal

TNCY

A disorder characterized by cyanosis in the fetus and neonate, due to a defect in the fetal hemoglobin chain which has reduced affinity for oxygen. Some patients develop anemia resulting from increased destruction of red cells containing abnormal or unstable hemoglobin. The cyanosis resolves spontaneously by 5 to 6 months of age or earlier, as the adult beta-globin chain is produced and replaces the fetal gamma-globin chain.

None

The disease is caused by variants affecting the gene represented in this entry.

Post-translational modifications

Acetylation of Gly-2 converts Hb F to the minor Hb F1.

Sequence similarities

Belongs to the globin family.

Tissue specificity

Red blood cells.

Alternative names

  • Hemoglobin subunit gamma-2
  • Gamma-2-globin
  • Hb F Ggamma
  • Hemoglobin gamma-2 chain
  • Hemoglobin gamma-G chain
  • HBG2

Target type

Proteins

Molecular weight

16126Da