HCAR1
Function
Acts as a receptor for L-lactate and mediates its anti-lipolytic effect through a G(i)-protein-mediated pathway.
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Tissue Specificity
Expressed abundantly in brown and white fat. It also detectable at lower levels in liver, kidney, skeletal muscle, brain and pituitary. Not detected in frontal, temporal and occipital lobes of the cortex, basal forebrain, caudate nucleus, nucleus accumbens and hippocampus.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
GPR104, GPR81, HCA1, FKSG80, HCAR1, Hydroxycarboxylic acid receptor 1, G-protein coupled receptor 104, G-protein coupled receptor 81