HCLS1 phospho Y397
Developmental stage
Expressed in early stage of myeloid and erythroid differentiation.
Function
Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.
Post-translational modifications
Phosphorylated by FES (By similarity). Phosphorylated by LYN, FYN and FGR after cross-linking of surface IgM on B-cells. Phosphorylation by LYN, FYN and FGR requires prior phosphorylation by SYK or FES.
Tissue Specificity
Expressed only in tissues and cells of hematopoietic origin.
Cellular localization
- Membrane
- Peripheral membrane protein
- Cytoplasm
- Mitochondrion
Alternative names
HS1, HCLS1, Hematopoietic lineage cell-specific protein, Hematopoietic cell-specific LYN substrate 1, LckBP1, p75