Hcn1
Domain
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
Function
Hyperpolarization-activated ion channel that are permeable to sodium and potassium ions. Exhibits weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih) (By similarity). Participates in cerebellar mechanisms of motor learning (By similarity). May mediate responses to sour stimuli (PubMed:11675786).
Sequence Similarities
Belongs to the potassium channel HCN family.
Tissue Specificity
Highly expressed in cerebral cortex, cerebellum, throughout the hippocampus, in medial habenula, anterior dorsal nucleus in the thalamus, tenia tecta, several nuclei of the general motor system and in optic nerve layer. Detected in a subset of elongated cells in taste buds.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, Hcn1