HCN3
Domain
The segment S4 is the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. The ion-conducting pore region is between segment S5 and S6.
Function
Hyperpolarization-activated ion channel that are permeable to sodium and potassium ions, with an about 3:1 preference for potassium ions (PubMed:16043489). Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). In particular, plays a pivotal role in maintaining excitability and promoting rhythmic burst firing within hypothalamic nuclei. Exerts a significant influence on the configuration of the cardiac action potential waveform. Does not appear to play a prominent role in the processing of acute, neuropathic, or inflammatory pain (By similarity).
Sequence Similarities
Belongs to the potassium channel HCN family.
Tissue Specificity
Detected in brain.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
KIAA1535, HCN3, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3