Orexin receptor type 2

The N-terminal region is required for orexin signaling.

Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides (PubMed:26950369, PubMed:9491897). Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding (PubMed:26950369, PubMed:9491897).

Belongs to the G-protein coupled receptor 1 family.

• Cell membrane
• Multi-pass membrane protein

Orexin receptor type 2, Ox-2-R, Ox2-R, Ox2R, Hypocretin receptor type 2, HCRTR2

• entrezGene:3062
• omim:602393
• swissprot:O43614

Proteins

Metabolism

50694Da