HDAC11
Function
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
Sequence Similarities
Belongs to the histone deacetylase family.
Tissue Specificity
Weakly expressed in most tissues. Strongly expressed in brain, heart, skeletal muscle, kidney and testis.
Cellular localization
- Nucleus
Alternative names
Histone deacetylase 11, HD11, HDAC11