Hdac6
Function
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:9891014). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:9891014). Histone deacetylases act via the formation of large multiprotein complexes (PubMed:9891014). In addition to histones, deacetylates other proteins, such as CTTN, tubulin and SQSTM1 (PubMed:19893491, PubMed:27737934). Plays a central role in microtubule-dependent cell motility by mediating deacetylation of tubulin (PubMed:19893491, PubMed:27737934). Required for cilia disassembly; via deacetylation of alpha-tubulin (By similarity). Promotes deacetylation of CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy (By similarity). Promotes odontoblast differentiation following IPO7-mediated nuclear import and subsequent repression of RUNX2 expression (PubMed:35922041). In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome (By similarity). Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy (PubMed:22819792).
Post-translational modifications
Phosphorylated by AURKA; phosphorylation increases HDAC6-mediated deacetylation of alpha-tubulin and subsequent disassembly of cilia.
Ubiquitinated. Its polyubiquitination however does not lead to its degradation.
Sumoylated in vitro.
Sequence Similarities
Belongs to the histone deacetylase family. HD type 2 subfamily.
Tissue Specificity
Expressed in neurons of the cortex. Expressed in Purkinje cells. Detected in keratinocytes (at protein level).
Cellular localization
- Cytoplasm
- Cytoplasm
- Cytoskeleton
- Nucleus
- Perikaryon
- Cell projection
- Dendrite
- Cell projection
- Axon
- Cell projection
- Cilium
- Cytoplasm
- Cytoskeleton
- Microtubule organizing center
- Centrosome
- Cytoplasm
- Cytoskeleton
- Cilium basal body
- It is mainly cytoplasmic, where it is associated with microtubules.
Alternative names
Histone deacetylase 6, HD6, Histone deacetylase mHDA2, Protein deacetylase HDAC6, Tubulin-lysine deacetylase HDAC6, Hdac6