Hdac7
Function
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:10640276, PubMed:10984530, PubMed:11279209). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:10640276, PubMed:10984530, PubMed:11279209). Histone deacetylases act via the formation of large multiprotein complexes (PubMed:10640276, PubMed:10984530, PubMed:11279209). Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C (PubMed:11279209). During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (PubMed:11279209). Positively regulates the transcriptional repressor activity of FOXP3 (By similarity). Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding (By similarity). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (By similarity). Also acetylates non-histone proteins, such as ALKBH5 (By similarity).
Post-translational modifications
May be phosphorylated by CaMK1. Phosphorylated by the PKC kinases PKN1 and PKN2, impairing nuclear import. Phosphorylation at Ser-178 by MARK2, MARK3 and PRKD1 promotes interaction with 14-3-3 proteins and export from the nucleus. Phosphorylation at Ser-178 is a prerequisite for phosphorylation at Ser-204 (By similarity).
Sequence Similarities
Belongs to the histone deacetylase family. HD type 2 subfamily.
Tissue Specificity
Highly expressed in heart and lung. Expressed at intermediate level in muscle.
Cellular localization
- Nucleus
- Cytoplasm
- In the nucleus, it associates with distinct subnuclear dot-like structures (PubMed:10640276). Shuttles between the nucleus and the cytoplasm (PubMed:11279209, PubMed:11585834). In muscle cells, it shuttles into the cytoplasm during myocyte differentiation (PubMed:11279209). The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and is due to its phosphorylation (PubMed:11585834).
Alternative names
Hdac7a, Histone deacetylase 7, HD7, Histone deacetylase 7A, Protein deacetylase HDAC7, HD7a