HEATR5B
Function
Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025).
Sequence Similarities
Belongs to the HEATR5 family.
Cellular localization
- Cytoplasm
- Perinuclear region
- Cytoplasmic vesicle
- Clathrin-coated vesicle
- Localization at clathrin-coated vesicles depends on AFTPH/aftiphilin.
Alternative names
KIAA1414, p200, p200a, HEATR5B, HEAT repeat-containing protein 5B