HECTD1
Function
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:33711283). Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion (By similarity). Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure (By similarity). Catalyzes ubiquitination and degradation of ZNF622, an assembly factor for the ribosomal 60S subunit, in hematopoietic cells, thereby promoting hematopoietic stem cell renewal (PubMed:33711283).
Pathway
Protein modification; protein ubiquitination.
Sequence Similarities
Belongs to the UPL family. K-HECT subfamily.
Alternative names
KIAA1131, HECTD1, E3 ubiquitin-protein ligase HECTD1, E3 ligase for inhibin receptor, HECT domain-containing protein 1, EULIR