Heme oxygenase 2
Function
Heme oxygenase 2
Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron.
Heme oxygenase 2 soluble form
Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron.
Post-translational modifications
A soluble form arises by proteolytic removal of the membrane anchor.
S-nitrosylated by BLVRB.
Sequence Similarities
Belongs to the heme oxygenase family.
Tissue Specificity
Widely distributed in body with a high concentration in the brain.
Cellular localization
- Microsome membrane
- Single-pass type IV membrane protein
- Cytoplasmic side
- Endoplasmic reticulum membrane
- Single-pass type IV membrane protein
- Cytoplasmic side
Alternative names
Heme oxygenase 2, HO-2, Hmox2