HENMT1
Function
Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis.
Sequence Similarities
Belongs to the methyltransferase superfamily. HEN1 family.
Cellular localization
- Cytoplasm
- Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis.
Alternative names
C1orf59, HENMT1, Small RNA 2'-O-methyltransferase, HEN1 methyltransferase homolog 1