HES5

Domain

Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).

The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.

Function

Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator (By similarity).

Tissue Specificity

Expressed in fetal heart and brain tumors.

Cellular localization

• Nucleus

Alternative names

BHLHB38, HES5, Transcription factor HES-5, Class B basic helix-loop-helix protein 38, Hairy and enhancer of split 5, bHLHb38

Database links

swissprot:Q5TA89 entrezGene:388585 omim:607348

Other research areas

• Epigenetics