Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.
Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator (By similarity).
Expressed in fetal heart and brain tumors.
BHLHB38, HES5, Transcription factor HES-5, Class B basic helix-loop-helix protein 38, Hairy and enhancer of split 5, bHLHb38
Proteins
Oncology
18226Da
We found 3 products in 1 category
ab25374