HEXIM2
Domain
The coiled-coil domain mediates oligomerization.
Function
Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:15713661, PubMed:15713662). Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:15713661, PubMed:15713662).
Sequence Similarities
Belongs to the HEXIM family.
Tissue Specificity
Ubiquitously expressed with higher expression in testis. HEXIM1 and HEXIM2 are differentially expressed.
Cellular localization
- Nucleus
Alternative names
L3, HEXIM2, Protein HEXIM2, Hexamethylene bis-acetamide-inducible protein 2