HEXIM2

The coiled-coil domain mediates oligomerization.

Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:15713661, PubMed:15713662). Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:15713661, PubMed:15713662).

Belongs to the HEXIM family.

Ubiquitously expressed with higher expression in testis. HEXIM1 and HEXIM2 are differentially expressed.

• Nucleus

L3, HEXIM2, Protein HEXIM2, Hexamethylene bis-acetamide-inducible protein 2

• entrezGene:124790
• omim:615695
• swissprot:Q96MH2

Proteins

32419Da