HEY2
Function
Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.
Sequence Similarities
Belongs to the HEY family.
Cellular localization
- Nucleus
Alternative names
BHLHB32, CHF1, GRL, HERP, HERP1, HRT2, HEY2, Hairy/enhancer-of-split related with YRPW motif protein 2, Cardiovascular helix-loop-helix factor 1, Class B basic helix-loop-helix protein 32, HES-related repressor protein 2, Hairy and enhancer of split-related protein 2, Hairy-related transcription factor 2, Protein gridlock homolog, hCHF1, bHLHb32, HESR-2, HRT-2, hHRT2