Hgf

Function

Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types (PubMed:20624990). Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity). Activates MAPK signaling following TMPRSS13 cleavage and activation (By similarity).

Post-translational modifications

The single-chain precursor undergoes proteolytic processing by TMPRSS13 resulting in an active two-chain form.

Sequence Similarities

Belongs to the peptidase S1 family. Plasminogen subfamily.

Alternative names

Hepatocyte growth factor, Hepatopoietin-A, Scatter factor, SF, Hgf

Database links

swissprot:Q08048 entrezGene:15234

Other research areas

• Immuno-oncology