HGF
GeneName
HGF
Summary
HGF, also known as hepatocyte growth factor or scatter factor, is an 83 kDa protein that primarily functions as a growth factor and chemoattractant. It is secreted into the extracellular region and plays a crucial role in various biological processes, including cell chemotaxis, epithelial cell proliferation, and liver development. HGF exerts its effects by binding to the hepatocyte growth factor receptor (MET), activating signalling pathways that promote cell migration, morphogenesis, and survival. It is involved in epithelial to mesenchymal transition and has implications in myoblast proliferation and the regulation of apoptosis and inflammation.
Importance
HGF is relevant to: - Tissue regeneration and repair mechanisms, particularly in the liver and skeletal muscle, due to its role in promoting cell proliferation and migration. - Cancer biology, as it can influence tumour growth and metastasis through its effects on cell migration and epithelial to mesenchymal transition. - Fibrosis and wound healing, where it may modulate inflammatory responses and tissue remodelling. - Developmental biology, given its involvement in liver development and organ morphogenesis.
Top Products
For researchers investigating HGF, we highly recommend the top-selling recombinant antibody, Anti-HGF antibody [EPR12230] (ab178395). This antibody has been validated for use in Western blotting (WB) and immunoprecipitation (IP), making it a versatile tool for your research needs. With 17 citations, it is well-regarded in the scientific community, reflecting its reliability and effectiveness in HGF detection. This recombinant antibody offers the added benefit of batch-to-batch consistency, ensuring dependable results in your experiments. The Recombinant human HGF protein (Active) ELISA Kit (ab259401), supported by 2 citations, is an excellent option for researchers looking to accurately measure HGF levels in their experiments.
Abcam Product Citation Summary
The data indicates that HGF is being studied in the context of cancer resistance and liver cirrhosis. The use of Abcam antibodies in Western blotting highlights their role in detecting HGF in various biological contexts, including human lung cancer and rat liver tissue.
Abcam Product Citation Table
Function
Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types (PubMed:20624990). Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (PubMed:15167892, PubMed:20977675). Activates MAPK signaling following TMPRSS13 cleavage and activation (PubMed:20977675).
Involvement in disease
Deafness, autosomal recessive, 39
DFNB39
A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
None
The disease is caused by variants affecting the gene represented in this entry.
Post-translational modifications
The single-chain precursor undergoes proteolytic processing by TMPRSS13 resulting in an active two-chain form.
Sequence Similarities
Belongs to the peptidase S1 family. Plasminogen subfamily.
Alternative names
HPTA, HGF, Hepatocyte growth factor, Hepatopoietin-A, Scatter factor, SF
Database links
Other research areas
- Immuno-oncology