HGF

Function

Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types (PubMed:20624990). Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (PubMed:15167892, PubMed:20977675). Activates MAPK signaling following TMPRSS13 cleavage and activation (PubMed:20977675).

Involvement in disease

Deafness, autosomal recessive, 39

DFNB39

A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.

None

The disease is caused by variants affecting the gene represented in this entry.

Post-translational modifications

The single-chain precursor undergoes proteolytic processing by TMPRSS13 resulting in an active two-chain form.

Sequence Similarities

Belongs to the peptidase S1 family. Plasminogen subfamily.

Alternative names

HPTA, HGF, Hepatocyte growth factor, Hepatopoietin-A, Scatter factor, SF

Database links

swissprot:P14210 omim:142409 entrezGene:3082

Other research areas

• Immuno-oncology