HHEX
Developmental stage
Expressed during hematopoiesis.
Function
Recognizes the DNA sequence 5'-ATTAA-3' (By similarity). Transcriptional repressor (By similarity). Activator of WNT-mediated transcription in conjunction with CTNNB1 (PubMed:20028982). Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity). Inhibits EIF4E-mediated mRNA nuclear export (PubMed:12554669). May play a role in hematopoietic differentiation (PubMed:8096636).
Tissue Specificity
Liver and promyelocytic leukemia cell line HL-60.
Cellular localization
- Nucleus
- Nucleus
- Nuclear body
- Cytoplasm
Alternative names
HEX, PRH, PRHX, HHEX, Hematopoietically-expressed homeobox protein HHEX, Homeobox protein HEX, Homeobox protein PRH, Proline-rich homeodomain protein