HHIP
Domain
A flexible loop interacts with the SHH zinc binding site and contributes to zinc binding.
Function
Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family.
Sequence Similarities
Belongs to the HHIP family.
Tissue Specificity
Widely expressed in fetal and adult tissues. Highest expression in adult heart, liver and pancreas, and in fetal kidney.
Cellular localization
- Cell membrane
- Peripheral membrane protein
- Secreted
- The last 22 C-terminal amino acids may participate in cell membrane attachment.
- Isoform 2
- Cytoplasm
Alternative names
HIP, UNQ5825/PRO19644, HHIP, Hedgehog-interacting protein