HILPDA
Function
Increases intracellular lipid accumulation. Stimulates expression of cytokines including IL6, MIF and VEGFA. Enhances cell growth and proliferation.
Tissue Specificity
Highly expressed in renal cell carcinoma cells but barely detectable in adjacent normal kidney tissue. Detected in some cervical and endometrial cancers. Expression also detected in fetal kidney with little or no expression observed in normal adult heart, liver, lung, pancreas, prostate or spinal cord (at protein level).
Cellular localization
- Lipid droplet
- Secreted
- Membrane
- Single-pass membrane protein
Alternative names
C7orf68, HIG2, HILPDA, Hypoxia-inducible lipid droplet-associated protein, Hypoxia-inducible gene 2 protein