HINT3
Function
Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (PubMed:17870088). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase (PubMed:17870088). Hydrolyzes 3-indolepropionic acyl-adenylate and fluorogenic purine nucleoside tryptamine phosphoramidates in vitro (PubMed:17870088).
Sequence Similarities
Belongs to the HINT family.
Cellular localization
- Cytoplasm
- Nucleus
- Localized as aggregates in the cytoplasm and the nucleus.
Alternative names
Adenosine 5'-monophosphoramidase HINT3, Histidine triad nucleotide-binding protein 3, HINT-3, HINT3