HIP1R
Domain
Binds F-actin via the talin-like I/LWEQ domain.
Function
Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis.
Sequence Similarities
Belongs to the SLA2 family.
Tissue Specificity
Brain, heart, kidney, pancreas, and liver, but not in lung or placenta.
Cellular localization
- Cytoplasm
- Perinuclear region
- Endomembrane system
- Cytoplasmic vesicle
- Clathrin-coated vesicle membrane
- Membrane-associated protein, mainly localized at the endocytic compartments and in the perinuclear region.
Alternative names
HIP12, KIAA0655, HIP1R, Huntingtin-interacting protein 1-related protein, HIP1-related protein, Huntingtin-interacting protein 12, HIP-12