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HIRA/HIR

OverviewProducts

Developmental stage

Expressed during embryogenesis.

Function

Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.

Post-translational modifications

Sumoylated.

Phosphorylated by CDK2/CCNA1 and CDK2/CCNE1 on Thr-555 in vitro. Also phosphorylated on Thr-555 and Ser-687 in vivo.

Sequence similarities

Belongs to the WD repeat HIR1 family.

Tissue specificity

Expressed at high levels in kidney, pancreas and skeletal muscle and at lower levels in brain, heart, liver, lung, and placenta.

Cellular localization

  • Nucleus
  • Nucleus
  • PML body
  • Primarily, though not exclusively, localized to the nucleus. Localizes to PML bodies immediately prior to onset of senescence.

Alternative names

  • Protein HIRA
  • TUP1-like enhancer of split protein 1
  • TUPLE1
  • HIR
  • DGCR1
  • HIRA

Database links

Target type

Proteins

Primary research area

Epigenetics

Molecular weight

111835Da