Histamine N-methyltransferase
Function
Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
Involvement in disease
Intellectual developmental disorder, autosomal recessive 51
MRT51
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
None
The disease is caused by variants affecting distinct genetic loci, including the gene represented in this entry.
Sequence Similarities
Belongs to the class I-like SAM-binding methyltransferase superfamily. HNMT family.
Cellular localization
- Cytoplasm
Alternative names
Histamine N-methyltransferase, HMT, HNMT