Contains two sets of 2 zinc-fingers, which are widely separated and recognize the same DNA sequence. There is a fifth zinc-finger in-between.
This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis.
ZNF40, HIVEP1, Zinc finger protein 40, Cirhin interaction protein, Gate keeper of apoptosis-activating protein, Human immunodeficiency virus type I enhancer-binding protein 1, Major histocompatibility complex-binding protein 1, Positive regulatory domain II-binding factor 1, CIRIP, GAAP, HIV-EP1, MBP-1, PRDII-BF1
Proteins
Oncology
296865Da
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