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HJURP

OverviewProducts

Function

Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions.

Tissue specificity

According to PubMed:17256767, highly expressed in the thymus with lower levels in the placenta, small intestine, liver, skeletal muscle, and colon. According to PubMed:17823411, highly expressed in testis, and at a relatively lower level in thymus and bone marrow. Significantly overexpressed in many lung cancer samples, compared with normal lung.

Cellular localization

  • Nucleus
  • Nucleolus
  • Chromosome
  • Centromere
  • Localizes in centromeres during late telophase and early G1, when CENPA nucleosomes are assembled. Localizes to nucleolus during S phase, nucleolus site being often related to storage.

Alternative names

  • Holliday junction recognition protein
  • 14-3-3-associated AKT substrate
  • Fetal liver-expressing gene 1 protein
  • Up-regulated in lung cancer 9
  • HJURP
  • FAKTS
  • FLEG1
  • URLC9

Database links

Target type

Proteins

Primary research area

Epigenetics

Molecular weight

83539Da