HLA-DMB
Domain
The YXXZ (Tyr-Xaa-Xaa-Zaa, where Zaa is a hydrophobic residue) motif mediates the targeting to the lysosomal compartments.
Function
Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.
Sequence Similarities
Belongs to the MHC class II family.
Cellular localization
- Late endosome membrane
- Single-pass type I membrane protein
- Lysosome membrane
- Single-pass type I membrane protein
- Localizes to late endocytic compartment. Associates with lysosome membranes.
Alternative names
DMB, RING7, HLA-DMB, MHC class II antigen DMB, Really interesting new gene 7 protein