HLA-DOB
Function
Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.
Sequence Similarities
Belongs to the MHC class II family.
Cellular localization
- Endosome membrane
- Single-pass type I membrane protein
- Lysosome membrane
- Single-pass type I membrane protein
- Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments. Heterotetramerization is necessary to exit the ER.
Alternative names
MHC class II antigen DOB, HLA-DOB