HLTF
Function
Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA.
Pathway
Protein modification; protein ubiquitination.
Sequence Similarities
Belongs to the SNF2/RAD54 helicase family. RAD16 subfamily.
Tissue Specificity
Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle.
Cellular localization
- Cytoplasm
- Nucleus
- Nucleus
- Nucleolus
- Nucleus
- Nucleoplasm
- Nuclear localization is stimulated by progesterone.
Alternative names
HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1, HLTF, Helicase-like transcription factor, DNA-binding protein/plasminogen activator inhibitor 1 regulator, HIP116, RING finger protein 80, RING-type E3 ubiquitin transferase HLTF, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3, Sucrose nonfermenting protein 2-like 3