Hmga2
Developmental stage
Expressed predominantly during embryogenesis. In myogenic progenitor cells, expressed during early myogenic development (11.5 dpc) to be gradually down-regulated during the fetal stages (17.5 dpc) (PubMed:27446912).
Function
Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation (PubMed:27446912). Positively regulates IGF2 expression through PLAG1 and in a PLAG1-independent manner (By similarity).
Post-translational modifications
Regulated by cell cycle-dependent phosphorylation which alters its DNA binding affinity. Phosphorylated by NEK2.
Sequence Similarities
Belongs to the HMGA family.
Tissue Specificity
Expressed in mitotic spermatogonia, meiotic spermatocytes, and postmeiotic round spermatids (at protein level) (PubMed:14668482). Expressed in embryonic myogenic progenitor cells (PubMed:27446912).
Cellular localization
- Nucleus
Alternative names
Hmgic, High mobility group protein HMGI-C, High mobility group AT-hook protein 2