HMGCLL1
Function
Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues.
Pathway
Metabolic intermediate metabolism; (S)-3-hydroxy-3-methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1.
Sequence Similarities
Belongs to the HMG-CoA lyase family.
Cellular localization
- Cytoplasm
- Cytosol
- Endoplasmic reticulum membrane
- Peripheral membrane protein
Alternative names
3-hydroxy-3-methylglutaryl-CoA lyase-like protein 1, Endoplasmic reticulum 3-hydroxy-3-methylglutaryl-CoA lyase, HMGCL-like 1, er-cHL, HMGCLL1