HMGCS1
Function
Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis.
Pathway
Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 2/3.
Sequence Similarities
Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
Cellular localization
- Cytoplasm
Alternative names
HMGCS, HMGCS1, HMG-CoA synthase, 3-hydroxy-3-methylglutaryl coenzyme A synthase